Author

Irene E. Whitney

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4 Genetics· 1

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Organism:mouse· 5 Assay:scRNA-seq· 4 Approach:statistical model· 4 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Joshua R. SanesiD· 5 shared Karthik ShekhariD· 3 shared Inbal BenhariD· 2 shared Mallory A. Laboulaye· 2 shared Nicholas M. TraniD· 2 shared Salwan ButrusiD· 2 shared Wenjun YaniD· 2 shared Anne JacobiiD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersNeuroscience

Joshua R. SanesORCID

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5 papers

Recent·Most cited

Vision-dependent and -independent molecular maturation of mouse retinal ganglion cells

Irene E. Whitney, Salwan Butrus, Michael A. Dyer, Fred M Rieke, Joshua R. Sanes, Karthik Shekhar

This study uses scRNA-seq to analyze molecular maturation of mouse retinal ganglion cells, showing visual activity is not required for type identity but is needed for full maturation.

Neuroscience · Jul 20, 2022Peer-reviewedNeuroscience

Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types

Karthik Shekhar, Irene E. Whitney, Salwan Butrus, Yi-Rong Peng, Joshua R. Sanes

This study uses single-cell RNA-seq to show that mouse retinal ganglion cell precursors diversify into discrete types through gradual fate restriction after mitosis.

eLife · Feb 22, 2022Peer-reviewedNeuroscience

MOLECULAR IDENTIFICATION OF SIXTY-THREE AMACRINE CELL TYPES COMPLETES A MOUSE RETINAL CELL ATLAS

Wenjun Yan, Mallory A. Laboulaye, Nicholas M. Tran, Irene E. Whitney, Inbal Benhar, Joshua R. Sanes

This paper identifies 63 amacrine cell types in the mouse retina using scRNA-seq and provides molecular markers, neurotransmitter profiles, and transcription factors for each type.

bioRxiv · Mar 10, 2020 · PreprintNeuroscience

Single-cell profiles of retinal neurons differing in resilience to injury reveal neuroprotective genes

Nicholas M. Tran, Karthik Shekhar, Irene E. Whitney, Anne Jacobi, Inbal Benhar, Guosong Hong, Wenjun Yan, Xian Adiconis, McKinzie E. Arnold, Jung Min Lee, Joshua Z. Levin, Dingchang Lin, Chen Wang, Charles M. Lieber, Aviv Regev, , Joshua R. Sanes

The paper identifies neuroprotective genes in retinal ganglion cells by analyzing their resilience to injury using single-cell RNA-seq and functional assays.

Neuron · Nov 26, 2019Peer-reviewedNeuroscience

Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes And Neighboring Endogenous Genes

Mallory A. Laboulaye, Xin Duan, Mu Qiao, Irene E. Whitney, Joshua R. Sanes

The paper maps transgene insertion sites in mice and shows that transgene integration affects neighboring endogenous gene expression.

Frontiers in Molecular Neuroscience · Oct 23, 2018Peer-reviewedGenetics