Author

Ana Ruiz Manzano

Washington University in St. LouisORCID 0000-0001-9135-1436Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Eric A. GalburtiD· 2 shared Alwyn M. V. EckeriD· 1 shared Drake JenseniD· 1 shared Natalie R. Sontag· 1 shared Shumin TaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersMicrobiology

Eric A. GalburtORCID

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2 papers

Recent·Most cited

MicrobiologyPLoS GeneticsPeer-reviewedFeb 12, 2026

Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates Mycobacterium tuberculosis sensitivity to nitric oxide stress

Natalie R. Sontag, Ana Ruiz Manzano, Alwyn M. V. Ecker…·Shumin Tan

This study shows that STPK phosphorylation of DosR in Mtb reduces its transcriptional activity and alters its response to nitric oxide stress, highlighting a regulatory interaction between STPKs and TCSs.

1 citation

bacteria (other)DNA methylation

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BiochemistryJournal of Biological ChemistryPeer-reviewedJun 12, 2025

Regulation of Steady State Ribosomal Transcription in Mycobacterium tuberculosis: Intersection of Sigma Subunits, Superhelicity, and Transcription Factors.

Ana Ruiz Manzano, Drake Jensen, Eric A. Galburt

This study quantifies rRNA transcription in Mtb, showing {sigma}A dominates over {sigma}B, with CarD and RbpA modulating superhelicity effects and N-terminal {sigma}A residues enhancing activity.

4 citations

bacteria (other)experimental assay

𝕏 PostBluesky