Dedifferentiation unlocks keratinocyte competence for metaplasia and tumorigenesis in the foregut
Alizée Vercauteren Drubbel, Sheleya Pirard, Benjamin Beck
The paper shows that GATA4 drives metaplasia and tumorigenesis in esophageal squamous progenitors, but not keratinocytes, and that Hedgehog signaling expansion enhances this process.
bioRxiv · Jun 25, 2026 · PreprintCancer Biology