Laurine Verset

A Luminal-Basal Stratification of the Native Human Pancreatic Duct is Differentially Represented in Pancreatic Cancers

This study identifies spatially distinct cell populations in human pancreatic ducts and shows that ASCP better preserves native cell identities compared to PDAC.

Glycation Stress-Driven Transcriptomic Signature Predicts Survival Benefit from Adjuvant Gemcitabine in Resectable Pancreatic Cancer.

The paper develops a 16-gene signature (MG-GEM) that predicts survival benefit from adjuvant gemcitabine in resectable pancreatic cancer based on glycation stress, outperforming existing signatures.

Sox9-dependent plasticity of esophageal progenitors is fine-tuned by cues from the microenvironment

The paper shows that Sox9-dependent plasticity in esophageal progenitors is regulated by Hedgehog-induced TGF-β and BMP pathways, and can be modulated by Ibuprofen in vivo.

Duodenal organoids from metabolic dysfunction-associated steatohepatitis patients exhibit altered digestive homeostasis

This study examines duodenal organoids from MASH patients and finds altered digestive homeostasis and junctional protein misexpression without barrier dysfunction.

Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after Total Neoadjuvant Therapy including Stereotactic Body Radiotherapy

This study shows that combining FOLFIRINOX with stereotactic body radiotherapy remodels pancreatic ductal adenocarcinoma, improving stromal and metabolic features and prognosis.