Structure and Mechanism of a Two-component Lanthipeptide Toxin
Ryan Moreira, Constantin Giurgiu, Imran R. Rahman, MacKenzie Patterson, Stefan T. Huber, Yi Yang, Kévin Jeanne Dit Fouque, Francisco Alberto Fernandez-Lima, Ge Liu, Ruihan Guo, Payam Kelich, Po‐Chao Wen, Emad Tajkhorshid, Alex G. Johnson, Wilfred A. van der Donk
The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.
bioRxiv · May 14, 2026 · PreprintBiochemistry