Author

Po-Chao Wen

University of Illinois Urbana-ChampaignORCID 0000-0002-6049-6904Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

Emad TajkhorshidiD· 2 shared Alex G. JohnsoniD· 1 shared Constantin GiurgiuiD· 1 shared Defne G. OzgulbasiD· 1 shared Francisco Alberto Fernandez-LimaiD· 1 shared Ge LiuiD· 1 shared Huibin LviD· 1 shared Imran R. RahmaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Emad TajkhorshidORCID

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2 papers

Recent·Most cited

Structure and Mechanism of a Two-component Lanthipeptide Toxin

Ryan Moreira, Constantin Giurgiu, Imran R. Rahman, MacKenzie Patterson, Stefan T. Huber, Yi Yang, Kévin Jeanne Dit Fouque, Francisco Alberto Fernandez-Lima, Ge Liu, Ruihan Guo, Payam Kelich, Po‐Chao Wen, Emad Tajkhorshid, Alex G. Johnson, Wilfred A. van der Donk

The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.

bioRxiv · May 14, 2026 · PreprintBiochemistry

Probing the Role of Membrane in Neutralizing Activity of Antibodies Against Influenza Virus

Defne G. Ozgulbas, Timothy J.C. Tan, Po-Chao Wen, Qi Wen Teo, Huibin Lv, Zhaleh Ghaemi, Martin Frank, Nicholas C. Wu, Emad Tajkhorshid

This study shows that antibodies against influenza virus neutralize by interacting with the viral membrane, and disrupting these interactions reduces their effectiveness.

Structure · Dec 19, 2025Peer-reviewedBiophysics