Author

Payam Kelich

University of Illinois Urbana-ChampaignORCID 0000-0002-6441-6326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Approach:machine learning (classical)· 1 Assay:metagenomics· 1

Frequent Co-Authors

Emad TajkhorshidiD· 2 shared Alex G. JohnsoniD· 1 shared Chih-Hsuan LaiiD· 1 shared Chittaranjan DasiD· 1 shared Constantin GiurgiuiD· 1 shared Dabin Jung· 1 shared Daniel Patrick FlahertyiD· 1 shared Elizaveta I. ShestoperovaiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Emad TajkhorshidORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Substrate biasing in UCHL5 proteoforms

Rishi S. Patel, Nipuni M. Pannala, Chih-Hsuan Lai, Manoj Kumar Sriramoju, Yongsheng Wang, Ting Cheng, Dabin Jung, Payam Kelich, Soroush Asadi, Elizaveta I. Shestoperova, Shalini Iyer, Emad Tajkhorshid, Daniel Patrick Flaherty, Eric R. Strieter, Shang‐Te Danny Hsu, Chittaranjan Das

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

Structure and Mechanism of a Two-component Lanthipeptide Toxin

Ryan Moreira, Constantin Giurgiu, Imran R. Rahman, MacKenzie Patterson, Stefan T. Huber, Yi Yang, Kévin Jeanne Dit Fouque, Francisco Alberto Fernandez-Lima, Ge Liu, Ruihan Guo, Payam Kelich, Po‐Chao Wen, Emad Tajkhorshid, Alex G. Johnson, Wilfred A. van der Donk

The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.

bioRxiv · May 14, 2026 · PreprintBiochemistry

BinderSpace: A Package for Sequence Space Analyses for Datasets of Affinity-Selected Oligonucleotides and Peptide-Based Molecules

Payam Kelich, Huanhuan Zhao, Jose R. Orona, Lela Vuković

BinderSpace is a Python package that analyzes sequence datasets of affinity-selected molecules to identify high-affinity binders through motif analysis, clustering, and visualization.

Journal of Computational Chemistry · May 12, 2023Peer-reviewedBioinformatics