B. Mohana Kumar

This study shows that PRC2 restricts naive pluripotent stem cells from differentiating into trophectoderm by maintaining bivalent promoters and H3K27me3 methylation.

This study uses TT-seq to analyze RNA synthesis dynamics in three mouse pluripotent states, finding reduced RNA synthesis and elongation velocity in 2i and mTORi states.

The paper uses MINUTE-ChIP to analyze H3K27me3 and H3K4me3 in mouse ESCs under 2i and serum conditions, finding hypermethylation of H3K27me3 and loss of H3K4me3 at bivalent promoters.