Fredrik Lanner

A Comprehensive Human Embryogenesis Reference Tool using Single-Cell RNA-Sequencing Data

The paper develops a comprehensive reference tool for human embryogenesis using integrated single-cell RNA-sequencing data to benchmark embryo models.

Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naive PSCs

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

Polycomb Repressive Complex 2 shields naïve human pluripotent cells from trophectoderm differentiation

This study shows that PRC2 restricts naive pluripotent stem cells from differentiating into trophectoderm by maintaining bivalent promoters and H3K27me3 methylation.

Amnion signals are essential for mesoderm formation in primates

The paper identifies ISL1's critical role in primate mesoderm formation through a transcriptional atlas and CRISPR experiments in non-human primates.

Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use

This study maps the single-cell transcriptomic dynamics of hESC-RPE differentiation, identifies an intermediate progenitor, and shows in vivo maturation after transplantation.