Polycomb Repressive Complex 2 shields naïve human pluripotent cells from trophectoderm differentiation
B. Mohana Kumar, Carmen Navarro, Nerges Winblad, John Paul Schell, Cheng Zhao, Jere Weltner, Laura Baqué-Vidal, Angelo Salazar Mantero, Sophie Petropoulos A, Fredrik Lanner, Simon J. Elsässer
This study shows that PRC2 restricts naive pluripotent stem cells from differentiating into trophectoderm by maintaining bivalent promoters and H3K27me3 methylation.
Nature Cell Biology · May 30, 2022Peer-reviewedDevelopmental Biology