Author

Pablo Lazcano

Wayne State UniversityORCID 0000-0001-9218-5396Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Michael W. SchmidtkeiD· 2 shared Miriam L. GreenbergiD· 2 shared Chisom OnuiD· 1 shared Mária Balážová· 1 shared Michael SchlameiD· 1 shared Mindong ReniD· 1 shared Mohamed Chakkour· 1 shared Riekelt H. HoutkooperiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

Michael W. SchmidtkeORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintFeb 3, 2024

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells

Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke…·Miriam L. Greenberg

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

DOI 10.1101/2024.02.03.578755

mousemetabolomics

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Molecular BiologybioRxivPreprintFeb 21, 2022

Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of IP6K1 and repression of myo-inositol-3-P synthase

Pablo Lazcano, Michael W. Schmidtke, Chisom Onu, Miriam L. Greenberg

This study shows that phosphatidic acid (PA) inhibits inositol synthesis by promoting nuclear translocation of IP6K1 and reducing MIPS expression through the AMPK-PLD pathway.

5 citations

mouseexperimental assay

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