Michael Schlame

This study uses cryo-EM to capture high-resolution structures of the KdpFABC potassium pump in E. coli during active transport, revealing lipid interactions and functional roles in potassium movement.

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

This study shows that cardiolipin is essential for postnatal cardiac maturation by enabling mitochondrial cristae to accumulate OXPHOS proteins and protect them from degradation.