Author

Gwo‐Shu Mary Lee

Dana-Farber Cancer InstituteORCID 0000-0001-9236-9195Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:benchmarking· 2 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Toni K. ChoueiriiD· 3 shared Hunter SavignanoiD· 2 shared Ji-Heui SeoiD· 2 shared John CanniffiD· 2 shared Karl SemaaniD· 2 shared Marc EidiD· 2 shared Matthew L. FreedmaniD· 2 shared Sabina SignorettiiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Toni K. ChoueiriORCID

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3 papers

Recent·Most cited

Integrated inference of cancer gene expression from cell-free plasma chromatin

Gunsagar Singh Gulati, Damien Vasseur, Rashad Nawfal, Shahabeddin Sotudian, Karl Semaan, Marc Eid, Ji-Heui Seo, Noa Phillips, John Canniff, Hunter Savignano, Surya B. Chhetri, Zhenjie Jin, Yukun Ou, Mohamed Amine Bani, Gwo‐Shu Mary Lee, , Matthew L. Freedman

APEX infers cancer gene expression from plasma cfChIP-seq data, outperforming existing methods and enabling subtype classification and biomarker identification.

bioRxiv · Feb 19, 2026 · PreprintGenomics

TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma

Jiao Li, Kaimeng Huang, Meha Thakur, Fiona McBride, Ananthan Sadagopan, Daniel S Gallant, Prateek Khanna, Yasmin Nabil Laimon, Bingchen Li, Razan Assaad Mohanna, Maolin Ge, Cary N. Weiss, Mingkee Achom, Qingru Xu, Sayed Matar, , Srinivas Raghavan Viswanathan

This study identifies TFE3 fusions driving OXPHOS in tRCC and reveals EGLN1 inhibition as a therapeutic target.

Nature Metabolism · Feb 6, 2025Peer-reviewedCancer Biology

Epigenomic signatures as circulating and predictive biomarkers in sarcomatoid renal cell carcinoma

Talal El Zarif, Karl Semaan, Marc Eid, Ji-Heui Seo, Simon Garinet, Matthew P. Davidsohn, Pranshu Sahgal, Brad J. Fortunato, John Canniff, Amin H. Nassar, Sarah Abou Alaiwi, Ziad Bakouny, Gitanjali Lakshminarayanan, Hunter Savignano, Kevin Lyons, , Sylvan C. Baca

The paper identifies epigenomic signatures in sarcomatoid renal cell carcinoma (sRCC) that predict response to immune checkpoint inhibitors and are detectable in plasma, enabling non-invasive diagnosis.

Cell Reports · Jun 1, 2024Peer-reviewedGenomics