Jimmy K. Guo

SPIDR is a high-throughput method for mapping RNA-protein interactions that identifies 4EBP1's role in selectively repressing mRNA translation under mTOR inhibition.

ChIP-DIP enables simultaneous mapping of hundreds of regulatory proteins to DNA, revealing diverse regulatory elements and their functional activity.

The paper identifies that ignoring RNA quantity in analysis leads to inflated background signals and misleading conclusions about PRC2 and GFP RNA binding.

The paper demonstrates that the XIST RNA-protein complex has a modular architecture that determines RBP binding and m6A modification, beyond sequence motifs.