Author

Denise Ohnezeit

New York UniversityORCID 0000-0002-2346-2545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:long-read sequencing· 1 Assay:metagenomics· 1

Frequent Co-Authors

Angus C. WilsoniD· 3 shared Adam T SilhavyiD· 1 shared Adam T. GrundhoffiD· 1 shared Alejandro PirontiiD· 1 shared Carola Schneider· 1 shared Caroline C. FriedeliD· 1 shared Claudia S. SchmidtiD· 1 shared Daniel Pearce DepledgeiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

Angus C. WilsonORCID

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4 papers

Recent·Most cited

METTL3 promotes human coronavirus replication through an interferon-independent mechanism

Ikshitaa Dinesh, Joaquim Miguel dos Santos Fonseca, Denise Ohnezeit, Gillian Elliott, Angus C. Wilson, Hannah M. Burgess

This study shows METTL3 promotes human coronavirus replication without requiring interferon signaling.

bioRxiv · Sep 19, 2026 · PreprintMicrobiology

TDP-43 promotes efficient HSV-1 replication in human DRG-derived neurons

Shirley E. Braspenning, Denise Ohnezeit, Olivia A. DeGulis, Angus C. Wilson, Ian Mohr

This study shows TDP-43 promotes HSV-1 replication in human DRG-derived neurons by enhancing viral mRNA splicing, but not in epithelial cells or fibroblasts.

Journal of Virology · Dec 4, 2025Peer-reviewedMicrobiology

Calibrated analysis framework for nanopore direct RNA sequencing uncovers cell-specific m6A proportions at conserved sites

Denise Ohnezeit, Elene Loliashvili, Gregory Putzel, Ruth Verstraten, Adam T Silhavy, Jianheng Fox Liu, Luke S. Nicholson, Alejandro Pironti, Samie R. Jaffrey, Daniel Pearce Depledge, Angus C. Wilson

The paper evaluates Dorado basecalling for nanopore DRS to detect m6A modifications in RNA, finding that stringent filtering improves accuracy and revealing cell-type differences in m6A proportions at conserved sites.

bioRxiv · Nov 2, 2025 · PreprintBioinformatics

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

Denise Ohnezeit, Jiabin Huang, Ute Westerkamp, Veronika Brinschwitz, Claudia S. Schmidt, Thomas Günther, Manja Czech‐Sioli, Samira Weißelberg, Tabea Schlemeyer, Jacqueline Nakel, Julia Mai, Sabrina Schreiner, Carola Schneider, Caroline C. Friedel, Hella Schwanke, , Nicole Fischer

This study identifies a novel function of MCPyV small T antigen in suppressing the type I interferon response by reducing IRF9 levels, impacting immune evasion and tumor progression.

PLoS Pathogens · Aug 7, 2024Peer-reviewedMolecular Biology