Shanshan He

Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimers disease

This study shows that amyloid plaques disrupt oligodendrocyte proteostasis, leading to myelin loss in Alzheimer's disease.

SPACE: multimodal spatial CRISPR screening with whole-transcriptome readout at subcellular resolution in 3D models

SPACE enables spatial CRISPR screening with whole-transcriptome and protein readouts at subcellular resolution, revealing novel regulatory mechanisms in tumor microenvironments.

Insitutype: likelihood-based cell typing for single cell spatial transcriptomics

Insitutype types cells in spatial transcriptomics with a likelihood model over every expression value, admits image and neighbourhood priors, and is reported to cluster millions of cells quickly.

High-plex Multiomic Analysis in FFPE at Subcellular Level by Spatial Molecular Imaging

An automated in-situ imaging platform reads 980 RNAs and 108 proteins in FFPE tissue at subcellular resolution, with 0.0092 false calls per cell; 800,000-plus cells released publicly.

The genomic and transcriptomic foundations of viviparous seed development in mangroves

This study identifies genetic and transcriptomic changes associated with vivipary in mangroves, highlighting the loss of the DOG1 gene and altered hormone pathways.