Author

Alexandru M. Pleşa

Harvard UniversityORCID 0000-0002-0414-4285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

George McDonald ChurchiD· 3 shared George CaiiD· 2 shared Michael ShadpouriD· 2 shared Ali Doğa YüceliD· 1 shared Amy J. WagersiD· 1 shared Andrew L. JiiD· 1 shared Anna MandinovaiD· 1 shared Antonio del SoliD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersGenomics

George McDonald ChurchORCID

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3 papers

Recent·Most cited

Human skin rejuvenation via mRNA

Li Li, Zhengkuan Tang, Xavier Portillo, Rohit Arora, Madeleine Yang, Esther Mintzer, Zhenrui Zhang, Stefano Sol, Fabiana Boncimino, Patrick Han, Michelle Z. Dion, Emery Di Cicco, D.D. Majewski, Asaf Ashkenazy-Titelman, Alexandru M. Pleşa, , George McDonald Church

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

Journal of Investigative Dermatology · Jul 21, 2026Peer-reviewedSynthetic Biology

Architectural fragility of gene regulatory networks underlies hematopoietic stem cell aging

Harlan P. Stevens, Ali Doğa Yücel, Russell A. Gould, George Cai, Vadim N. Gladyshev, Alexandru M. Pleşa, George McDonald Church

The paper analyzes single-cell multiome data from human HSPCs to show aging-related rewiring of gene regulatory networks, leading to stress hyperactivation, myeloid bias, and identity loss.

bioRxiv · Jun 4, 2026 · PreprintGenomics

Transcriptomic reprogramming screen identifies SRSF1 as rejuvenation factor

Alexandru M. Pleşa, Sascha Jung, Helen H. Wang, Fawad Omar, Michael Shadpour, David Choy Buentello, Maria Camila Pérez-Matos, Naftali Horwitz, George Cai, Zhen‐Kai Ngian, Carol V. de Magalhaes, Amy J. Wagers, William B. Mair, Antonio del Sol, George McDonald Church

This study identifies SRSF1 as a rejuvenation factor through transcriptomic reprogramming, showing it improves cellular function and is linked to longevity.

bioRxiv · Nov 13, 2023 · PreprintGenomics