Author

Christopher M. Bourne

University of PennsylvaniaORCID 0000-0001-9290-4223Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Developmental Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1

Frequent Co-Authors

Ashutosh B. MahaleiD· 3 shared Bohdana M. Discher· 3 shared Cornelius Y. TaabazuingiD· 3 shared Madhura Kulkarni· 3 shared Patrick M. ExcondeiD· 3 shared Robert C. Patio· 3 shared Matilda Kardhashi· 2 shared Mirai Kambayashi· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSynthetic Biology

Ashutosh B. MahaleORCID

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Author profile →

4 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintAug 27, 2026

DIPTAR: A synthetic biology platform for functional interrogation of protein degradation

Patrick M. Exconde, William Yoo, Madhura Kulkarni…·Cornelius Y. Taabazuing

DIPTAR converts protein degradation into a selectable phenotype to enable functional studies of degradation pathways and host-pathogen interactions.

DOI 10.64898/2026.08.26.747229

humanproteomics

Cell BiologyPLoS PathogensPeer-reviewedApr 27, 2026

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.

Madhura Kulkarni, Christopher M. Bourne, Ashutosh B. Mahale…·Cornelius Y. Taabazuing

This study identifies CASP4/5 as activators of CASP3/7 and GSDME in human macrophages, showing that CASP3 restricts Salmonella replication through apoptosis.

1 citation

humanproteomics

BiochemistrybioRxivPreprintFeb 23, 2025

Chemical Tools Based on the Tetrapeptide Sequence of IL-18 Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases

Christopher M. Bourne, Nicole R. Raniszewski, Madhura Kulkarni…·Cornelius Y. Taabazuing

The paper develops a new peptide-based inhibitor targeting caspase-8 and reveals shared specificities between inflammatory and apoptotic caspases.

2 citations

humanproteomics

Developmental BiologyDevelopmental BiologyPeer-reviewedJul 20, 2022

Regulators of the secretory pathway have distinct inputs into single-celled branching morphogenesis and seamless tube formation in the Drosophila trachea

Christopher M. Bourne, Daniel Lai, Jodi Schottenfeld-Roames

The paper investigates the role of secretory pathway components in Drosophila tracheal terminal cell morphogenesis, showing distinct contributions to basal and apical membrane growth.

9 citations

Drosophilaexperimental assay