Author

Ashutosh B. Mahale

University of PennsylvaniaORCID 0000-0002-9238-8262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Bohdana M. Discher· 3 shared Christopher M. BourneiD· 3 shared Cornelius Y. TaabazuingiD· 3 shared Madhura Kulkarni· 3 shared Patrick M. ExcondeiD· 3 shared Robert C. Patio· 3 shared Matilda Kardhashi· 2 shared Mirai Kambayashi· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSynthetic Biology

Bohdana M. Discher

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3 papers

Recent·Most cited

DIPTAR: A synthetic biology platform for functional interrogation of protein degradation

Patrick M. Exconde, William Yoo, Madhura Kulkarni, Ashutosh B. Mahale, Benjamin E Myers, Robert C. Patio, Christopher M. Bourne, Bohdana M. Discher, Cornelius Y. Taabazuing

DIPTAR converts protein degradation into a selectable phenotype to enable functional studies of degradation pathways and host-pathogen interactions.

bioRxiv · Aug 27, 2026 · PreprintSynthetic Biology

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.

Madhura Kulkarni, Christopher M. Bourne, Ashutosh B. Mahale, Patrick M. Exconde, Cecelia Murphy, Haley T. Goodrow, Sofia Cervantes, Matilda Kardhashi, Mirai Kambayashi, William Yoo, Tristan J. Wrong, Robert C. Patio, Bohdana M. Discher, Cornelius Y. Taabazuing

This study identifies CASP4/5 as activators of CASP3/7 and GSDME in human macrophages, showing that CASP3 restricts Salmonella replication through apoptosis.

PLoS Pathogens · Apr 27, 2026Peer-reviewedCell Biology

Chemical Tools Based on the Tetrapeptide Sequence of IL-18 Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases

Christopher M. Bourne, Nicole R. Raniszewski, Madhura Kulkarni, Patrick M. Exconde, Sherry Liu, Winslow Yost, Tristan J. Wrong, Robert C. Patio, Ashutosh B. Mahale, Matilda Kardhashi, Teni Shosanya, Mirai Kambayashi, Bohdana M. Discher, Igor E. Brodsky, George M. Burslem, Cornelius Y. Taabazuing

The paper develops a new peptide-based inhibitor targeting caspase-8 and reveals shared specificities between inflammatory and apoptotic caspases.

bioRxiv · Feb 23, 2025 · PreprintBiochemistry