Morgan H. James

This study shows reducing astrocyte calcium in the nucleus accumbens core increases reward valuation and self-administration of sucrose and cocaine in rats.

The paper shows dopamine neurons support intracranial self-stimulation (ICSS) only at supraphysiological frequencies, not reflecting their role in reinforcement learning.

This study shows that rat anterior cingulate cortex activity reflects dynamic encoding of decision variables in a patch foraging task, but these signals are not directly involved in decision-making.

The paper demonstrates that chemogenetic activation of a retinal circuit prevents depression-like behaviors and LC noradrenergic system pathology caused by light deprivation.

This study shows that intermittent fentanyl self-administration in rats leads to addiction-like behaviors that are reversed by an orexin-1 receptor antagonist.

This study tests suvorexant's ability to reduce fentanyl-related addiction-like behaviors in rats, finding it effective in decreasing motivation and reinstatement without affecting locomotion or natural rewards.

This study shows that the number of lateral hypothalamus orexin neurons correlates with individual differences in cocaine demand and that reducing these neurons decreases cocaine motivation.

This study investigates the effects of the orexin-1 receptor antagonist SB-334867 on response inhibition and motivation in rats, finding it reduces motivation but not inhibitory control.

This study shows that demand elasticity in rats predicts addiction endophenotypes and the effectiveness of an orexin-1 receptor antagonist in reducing cocaine-seeking behavior.

This study shows that activating group III mGluRs in the lateral hypothalamus reduces orexin cell activity and suppresses cocaine-seeking behavior during abstinence.

This study shows that intermittent cocaine access increases orexin neuron activity in the lateral hypothalamus, contributing to addiction-like behaviors in rats.