Raphaël Genolet

This study shows that unpaired TCRα + TCRβ sequencing can train accurate TCR-epitope recognition predictors at lower cost than paired sequencing.

The paper introduces TCR specificity profiles to identify key determinants of TCR-epitope recognition and shows their ability to predict cross-reactivity and interpret machine learning models.

The paper identifies clonally expanded neuron-specific CD8+ T cells in anti-Ri AIE patients using an unbiased approach and shows they express KIR3DL1 and TOX.

The paper improves epitope prediction by integrating HLA-I ligand data and TCR recognition models, identifying potent SARS-CoV-2 CD8+ T-cell epitopes with experimental validation.