Philippe Guillaume

Key determinants of T cell epitope recognition revealed by TCR specificity profiles

The paper introduces TCR specificity profiles to identify key determinants of TCR-epitope recognition and shows their ability to predict cross-reactivity and interpret machine learning models.

Redirecting TCR specificity in regulatory T cells toward class I HLA antigens mediates tissue-specific homing

The paper redirects TCR specificity in regulatory T cells toward class I HLA antigens to enhance tissue-specific homing in Type 1 Diabetes.

Predictions of immunogenicity reveal potent SARS-CoV-2 CD8+ T-cell epitopes

The paper improves epitope prediction by integrating HLA-I ligand data and TCR recognition models, identifying potent SARS-CoV-2 CD8+ T-cell epitopes with experimental validation.

Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity

The paper identifies HLA-I binding motifs from peptidomics data to improve neo-antigen predictions and reveals allosteric regulation of HLA specificity.