Anthony M Rossi

Drosophila larval optic lobe single-cell RNA-seq and pseudotime analysis define a near-complete medulla neuroblast temporal transcription factor series, with Eyeless and Dichaete acting as regulatory hubs.

The paper shows that extrinsic Activin signaling modulates an intrinsic temporal program in Drosophila mushroom body neuroblasts, leading to increased neuronal diversity by affecting the production of beta neurons.