Mehmet Neset Özel

Temporal regulation of a spatial patterning factor in Drosophila neurogenesis

The paper shows that the same selector transcription factor can be regulated by different patterning axes through distinct enhancers in Drosophila neurogenesis, revealing a cis-regulatory mechanism for neuronal diversity.

Single-locus chromatin memory enables flexible spatial fate specification in the Drosophila visual system

The paper shows that single-locus chromatin memory in Drosophila medulla progenitors allows spatial identity to be faithfully executed or flexibly bypassed during neuronal fate specification.

Regulatory logic of neuronal differentiation in the Drosophila visual system

The paper identifies cell-type-specific enhancers and regulatory codes for neuronal differentiation in Drosophila using single-cell RNA and ATAC sequencing.

Semi-automatic Geometrical Reconstruction and Analysis of Filopodia Dynamics in 4D Two-Photon Microscopy Images

The paper develops a semi-automatic workflow for tracing and tracking filopodia in 4D two-photon microscopy images using intensity data without segmentation.

Morphological and functional convergence of visual projections neurons from diverse neurogenic origins in Drosophila

The paper identifies the developmental origins of LCNs in Drosophila using single-cell RNA sequencing and shows they arise from four distinct brain regions with different neurogenesis modes.

Establishment of terminal selector combinations in optic lobe neurons

The paper identifies spatial subdomains in the Drosophila medulla and links patterning mechanisms to terminal selector expression in neuronal types.

Coordinated control of neuronal differentiation and wiring by a sustained code of transcription factors

The paper identifies a sustained transcription factor code that defines neuronal diversity in Drosophila and shows how modifying this code can convert cell fates in vivo.

A comprehensive series of temporal transcription factors in the fly visual system

Drosophila larval optic lobe single-cell RNA-seq and pseudotime analysis define a near-complete medulla neuroblast temporal transcription factor series, with Eyeless and Dichaete acting as regulatory hubs.

Serial synapse formation through filopodial competition for synaptic seeding factors

The paper develops a 4D analysis method and computational model to show that filopodia compete for synaptic seeding factors, leading to serial synapse formation in Drosophila R7 photoreceptor axons.