Isabel Holguera

This paper uses a gene expression cartography algorithm to create a 3D atlas of the Drosophila optic lobe, identifying spatially compartmentalized cell types and gene patterns.

The paper links temporal and Notch identity of medulla neurons to their synaptic location and neuropil targeting depth in the adult Drosophila visual system.

The paper identifies spatial subdomains in the Drosophila medulla and links patterning mechanisms to terminal selector expression in neuronal types.

The paper identifies a sustained transcription factor code that defines neuronal diversity in Drosophila and shows how modifying this code can convert cell fates in vivo.

Drosophila larval optic lobe single-cell RNA-seq and pseudotime analysis define a near-complete medulla neuroblast temporal transcription factor series, with Eyeless and Dichaete acting as regulatory hubs.

The paper shows that Loaf protein levels in R7 photoreceptors and their synaptic partners determine axon targeting accuracy in Drosophila.