Félix Simon

Gene expression cartography of a developing neuronal structure

This paper uses a gene expression cartography algorithm to create a 3D atlas of the Drosophila optic lobe, identifying spatially compartmentalized cell types and gene patterns.

Temporal and Notch identity determine neuropil targeting depth and synapse location in the fly visual system

The paper links temporal and Notch identity of medulla neurons to their synaptic location and neuropil targeting depth in the adult Drosophila visual system.

Morphological and functional convergence of visual projections neurons from diverse neurogenic origins in Drosophila

The paper identifies the developmental origins of LCNs in Drosophila using single-cell RNA sequencing and shows they arise from four distinct brain regions with different neurogenesis modes.

Establishment of terminal selector combinations in optic lobe neurons

The paper identifies spatial subdomains in the Drosophila medulla and links patterning mechanisms to terminal selector expression in neuronal types.

Spatial patterning regulates neuron numbers in the Drosophila visual system

The paper shows that spatial patterning in the Drosophila visual system regulates the number of Distal medulla inhibitory interneurons through domain subdivision and morphogenetic signaling.

A comprehensive series of temporal transcription factors in the fly visual system

Drosophila larval optic lobe single-cell RNA-seq and pseudotime analysis define a near-complete medulla neuroblast temporal transcription factor series, with Eyeless and Dichaete acting as regulatory hubs.