The paper develops a macrocyclic peptide WJL-63 with high ACE2-binding affinity and characterizes its structure and potential for imaging applications.

Journal of Structural Biology X · Apr 23, 2026Peer-reviewedMolecular Biology

Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2

Jinling Wang, Darja Beyer, Christian Vaccarin, Yingfang He, Matthias Tanriver, Roger Benoit, Xavier Deupí, Linjing Mu, Jeffrey W. Bode, Roger Schibli, Cristina Müller

This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.

European Journal of Nuclear Medicine and Molecular Imaging · Jul 27, 2024Peer-reviewedPharmacology & Toxicology

Comparison of the tolerability of 161Tb- and 177Lu-labeled somatostatin analogues in the preclinical setting

Sarah D. Busslinger, Ana Katrina Mapanao, Kristel Kegler, Peter Bernhardt, Fabienne Flühmann, Julia Fricke, Jan Rijn Zeevaart, U. Köster, Nicholas P. van der Meulen, Roger Schibli, Cristina Müller

This study compares the tolerability of 161Tb- and 177Lu-labeled somatostatin analogues in mice, finding that SSTR antagonists caused more hematologic changes than agonists, but both were safe at therapeutic activity levels.

European Journal of Nuclear Medicine and Molecular Imaging · Jul 24, 2024Peer-reviewedCancer Biology