Roger Benoit

The paper presents the cryo-EM structure of a β1-adrenoceptor-AmpC β-lactamase fusion protein in the inactive state, revealing conformational dynamics and potential for GPCR structure elucidation.

The paper develops a macrocyclic peptide WJL-63 with high ACE2-binding affinity and characterizes its structure and potential for imaging applications.

This paper develops and evaluates radiofluorinated derivatives of MLN-4760 for PET imaging of ACE2, finding that [18F]F-MLN-4760 shows superior binding affinity and yield.

The paper demonstrates that the ER/K motif (SAH) can rigidly connect protein domains, enabling the formation of ordered crystals and new applications in protein nanotechnology.