Andreia Albuquerque-Wendt

This study shows that the v-ATPase in Leishmania mexicana regulates lysosomal pH and is essential for stress responses, with a role in autophagy and parasite differentiation.

The paper identifies 34 transporter genes essential for Leishmania promastigote survival in sand flies, with V-ATPase subunits critical for parasite differentiation and life cycle progression.

This study shows that flagellum assembly and BBSome integrity are essential for Leishmania mexicana pathogenicity, while flagellar motility is not required for infection.

The paper identifies essential membrane transporters for Leishmania survival through a CRISPR-Cas9 gene deletion screen, finding that V-ATPase is critical for amastigote survival despite being dispensable for promastigote growth.