Çağla Alagöz

Vacuolar type H+ ATPase is involved in stress responses in Leishmania mexicana by regulating the lysosomal pH

This study shows that the v-ATPase in Leishmania mexicana regulates lysosomal pH and is essential for stress responses, with a role in autophagy and parasite differentiation.

Identification of transporters essential for survival of Leishmania promastigotes in the digestive tract of sand flies

The paper identifies 34 transporter genes essential for Leishmania promastigote survival in sand flies, with V-ATPase subunits critical for parasite differentiation and life cycle progression.

TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen

The paper identifies essential membrane transporters for Leishmania survival through a CRISPR-Cas9 gene deletion screen, finding that V-ATPase is critical for amastigote survival despite being dispensable for promastigote growth.