Author

H. Aitkenhead

Diamond Light SourceORCID 0000-0001-9365-6487Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

O. GileadiiD· 3 shared A. E. Handel· 1 shared A. Gavard· 1 shared A. Thompson· 1 shared Angeline E. Gavard· 1 shared B. G. Davis· 1 shared Carrow I. WellsiD· 1 shared D. Mamalis· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

O. GileadiORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 6, 2024

Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy

Joseph A. Newman, Angeline E. Gavard, Nergis Imprachim…·David Harold Drewry

This study determines the structure of human brachyury, identifies DNA binding insights and a G177D variant, and discovers small molecule binders for potential cancer therapy.

DOI 10.1101/2024.06.06.597736

humanprotein structure

𝕏 PostBluesky

BiochemistrybioRxivPreprintJul 26, 2022

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

M. Ye, M. Makola, J. Newman…·F. von Delft

The paper engineers nanobody interfaces to improve crystal reliability and diversity, resulting in better diffraction and multiple polymorphs.

DOI 10.1101/2022.07.26.501559

protein structureexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivSep 26, 2018

The structural basis for forkhead box family specificity revealed by the crystal structure of human FOXN1 in complex with DNA

J. A. Newman, H. Aitkenhead, A. Gavard…·O. Gileadi

This paper presents the crystal structure of human FOXN1 bound to DNA, revealing structural basis for its specificity and reduced affinity for methylated DNA.

DOI 10.1074/jbc.ra119.010365

humanstructural biology

𝕏 PostBluesky