Author

A. E. Handel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

F. Dhalla· 3 shared S. Maio· 3 shared G. A. Hollander· 2 shared I. A. Rota· 2 shared J. A. Newman· 2 shared M. E. Deadman· 2 shared O. GileadiiD· 2 shared S. Cheuk· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

F. Dhalla

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment

A. E. Handel, S. Cheuk, F. Dhalla, S. Maio, T. Hubscher, I. Rota, M. E. Deadman, O. Ekwall, M. Lutolf, K. Weinberg, G. Hollander

The paper uses single-cell profiling to analyze the dynamic changes in non-epithelial thymic stroma across development, identifying novel fibroblast subtypes and their roles in thymus organogenesis.

bioRxiv · Nov 8, 2021Immunology

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D. Charles, A. S. Gkazi, E. Adamopoulou, , G. A. Hollander

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

bioRxiv · Mar 28, 2021 · PreprintImmunology

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

C. P. Ponting, J. Baran-Gale, M. D. Morgan, S. Maio, F. Dhalla, I. Calvo-Asensio, M. Deadman, A. E. Handel, A. Maynard, S. Chen, F. Green, R. Sit, N. Neff, S. Darmanis, W. Tan, , G. A. Holländer

This study investigates how ageing affects mouse thymus function, revealing that progenitor cell differentiation is disrupted, leading to impaired T cell selection and self-antigen representation.

bioRxiv · Mar 2, 2020Immunology

The structural basis for forkhead box family specificity revealed by the crystal structure of human FOXN1 in complex with DNA

J. A. Newman, H. Aitkenhead, A. Gavard, I. A. Rota, A. E. Handel, G. A. Hollander, O. Gileadi

This paper presents the crystal structure of human FOXN1 bound to DNA, revealing structural basis for its specificity and reduced affinity for methylated DNA.

bioRxiv · Sep 26, 2018Biochemistry