Yukiko Gotoh

The paper identifies Polycomb repressive complexes (PRCs) as establishing TAD-scale H3K27me3 domains in mature neurons to maintain identity by silencing alternative lineage genes.

This study identifies age-related transcriptomic and epigenetic changes in mouse hippocampus, highlighting cell-type-specific alterations in chromatin accessibility and gene regulation.

The paper identifies CXCR2+ MDSC-like cells in the olfactory bulb that suppress antiviral immunity, leading to worse outcomes after VSV infection.

The paper identifies common and dataset-specific age-associated microglia populations across mouse and human datasets using integrative single-cell transcriptomic analysis.

The paper tracks chromatin accessibility changes in mouse embryonic deep-layer excitatory neurons during differentiation using RNA-seq and DNase-seq.

The paper identifies molecular mechanisms driving the divergence of adult neural stem cells and ependymal cells during embryogenesis through single-cell transcriptomic analysis.

This study shows that LPLAT11/MBOAT7 is essential for arachidonic acid incorporation into phosphatidylinositol, maintaining radial glial cell integrity and preventing cortical atrophy in developing neocortex.

This study shows neuronal micronuclei influence microglial states by altering their morphology and transcriptome during postnatal development.

This paper introduces a centrifugation-based method for high-throughput separation of supernatant from magnetic microbeads, offering a faster, cheaper, and more efficient alternative to manual pipetting and robotic systems.

The paper uses scHi-C data and the RPR method to analyze changes in chromosomal architecture during early embryogenesis, revealing intermingling of paternal/maternal chromosomes and Rabl-like polarization.

This study shows that Ring1, a Polycomb group protein, regulates ventral identity in the mouse telencephalon by suppressing BMP and Wnt signaling to allow Shh expression.

This study introduces a simple in utero injection method to introduce gene expression vectors into endo- and ectodermal cells of mouse embryos before neural tube closure, enabling tissue-specific labeling and analysis of gene function.

This study shows that the paternal allele of the p57Kip2 gene is expressed in the developing mouse neocortex and its deletion reduces brain size by decreasing neural stem-progenitor cells.