Hiroki Sugishita

Polycomb establishes TAD-scale H3K27me3 mega-domains to safeguard neuronal identity

The paper identifies Polycomb repressive complexes (PRCs) as establishing TAD-scale H3K27me3 domains in mature neurons to maintain identity by silencing alternative lineage genes.

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells

The paper identifies cooperative roles of Foxp3 and BATF in directing cis-regulatory programs and gene expression for Treg cell differentiation.

Type I IFN dynamics define an early checkpoint for survival and orchestrate systemic neutrophil heterogeneity in lethal viral infection

Local niche-derived immunosuppressive CXCR2+ cells impair antiviral immunity

The paper identifies CXCR2+ MDSC-like cells in the olfactory bulb that suppress antiviral immunity, leading to worse outcomes after VSV infection.

A centrifugation-based method for high-throughput biomaterial separation using magnetic microbeads

This paper introduces a centrifugation-based method for high-throughput separation of supernatant from magnetic microbeads, offering a faster, cheaper, and more efficient alternative to manual pipetting and robotic systems.

Preparation of "stress-free" concanavalin A-conjugated Dynabeads magnetic beads for CUT&Tag

The paper compares magnetic beads for CUT&Tag, finding that MyOne-T1 beads improve sensitivity due to better suspendability.

Changes of chromosomal architecture before establishment of chromosome territories revealed by recurrence plot reconstruction

The paper uses scHi-C data and the RPR method to analyze changes in chromosomal architecture during early embryogenesis, revealing intermingling of paternal/maternal chromosomes and Rabl-like polarization.

The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon

This study shows that Ring1, a Polycomb group protein, regulates ventral identity in the mouse telencephalon by suppressing BMP and Wnt signaling to allow Shh expression.

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

In silico integration of thousands of epigenetic datasets into 707 cell type regulatory annotations improves the trans-ethnic portability of polygenic risk scores

The paper integrates thousands of epigenetic datasets into 707 cell-type regulatory annotations to improve the trans-ethnic portability of polygenic risk scores by prioritizing variants in IMPACT regulatory elements.