Kyle Rapchak

This study shows that Brf1-mediated RNA polymerase III activity restricts murine gammaherpesvirus spread by enhancing host antiviral responses during low MOI infections.

This study shows that gammaherpesvirus infection leads to tRNA cleavage, producing tRNA fragments that are regulated by tRNA splicing factors and essential for viral replication.

This study shows that Hrq1/RECQL4 regulates DNA intrastrand crosslink repair and its misregulation contributes to genomic instability in cancer.

This study shows the yeast Shu complex prevents mutagenesis from 3meC lesions by binding to them and reducing replication errors.