Universal cancer tasks, evolutionary tradeoffs, and the functions of driver mutations
Jean Hausser, Pablo Szekely, Noam Bar, Anat Zimmer, Hila Sheftel, Carlos Caldas, Uri Alon
The paper introduces a theoretical framework to understand tumor diversity by identifying universal cancer tasks and showing driver mutations influence gene-expression specialization.
bioRxiv · Aug 1, 2018 · PreprintCancer Biology