Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P2
Giulia Russo, Nadja Hümpfer, Nina Jaensch, Steffen D. Restel, Christopher Schmied, Florian Heyd, Martin Lehmann, Helge Ewers, Volker Haucke, Michael I. Krauss
This study identifies septin-associated PIPKIγ splice variants as essential for midbody organization by generating PI(4,5)P2 required for centralspindlin recruitment and septin-microtubule association.
Nature Communications · Feb 7, 2026Peer-reviewedCell Biology