Daniela Barbosa

This study identifies ER-phagy as a negative regulator of myelin sheath thickness by degrading sphingolipid synthases in oligodendrocytes, preventing excessive myelination.

This study generates a genetically labeled premyelinating oligodendrocyte mouse line to study their morphology, transcriptomics, and role in axon ensheathment and neuronal activity.

This study shows autophagy promotes apoptosis in premyelinating oligodendrocytes to control myelination location, timing, and sheath thickness through the TFEB-PUMA-Bax/Bak pathway.