Lu O. Sun

Oligodendrocyte ER-phagy Restricts Excessive Myelination by Degrading Sphingolipid Synthases

This study identifies ER-phagy as a negative regulator of myelin sheath thickness by degrading sphingolipid synthases in oligodendrocytes, preventing excessive myelination.

Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity

This study generates a genetically labeled premyelinating oligodendrocyte mouse line to study their morphology, transcriptomics, and role in axon ensheathment and neuronal activity.

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase 1 promote oligodendrocyte development and myelination

Autophagy collaborates with apoptosis pathways to control myelination specificity and function

This study shows autophagy promotes apoptosis in premyelinating oligodendrocytes to control myelination location, timing, and sheath thickness through the TFEB-PUMA-Bax/Bak pathway.

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing

This study uses scRNA-seq to analyze microglia and myeloid cells across brain regions and developmental stages, revealing heterogeneity in postnatal microglia and their roles in disease.