Audrey R. Odom John

The cellular esterase FrmB controls metabolic homeostasis and small colony variant formation in Staphylococcus aureus

This study identifies FrmB as a serine hydrolase that regulates central carbon metabolism and small colony variant formation in S. aureus.

Machine learning enables de novo multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody

The paper designs a multi-epitope immunogen for malaria using machine learning, demonstrating its ability to bind and orient three copies of the L9 antibody.

Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling

This study detects CWD in deer using fecal VOCs, identifying specific compounds that distinguish infected from uninfected animals in both captive and wild populations.

Essential role for HSP40 in asexual replication and thermotolerance of malaria parasites

This study shows HSP40 is essential for malaria parasite asexual replication and survival at febrile temperatures, with a specific role in heat shock tolerance rather than proteotoxic stress.

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)

The paper identifies acylpeptide hydrolase (APEH) from red blood cells as an enzyme imported by malaria parasites that activates lipophilic ester prodrugs, offering a new strategy to overcome drug resistance.