M. Lisa Manning

The paper shows epithelial convergent extension can be viewed as a self-tuning process, with local feedback rules better reproducing experimental features than global optimization methods.

The paper develops a 3D vertex model to study how cell division orientation affects tissue mechanics during epithelial morphogenesis and explores its implications for cancer.

The paper shows that tissue mechanics control epithelial multilayering by regulating cell differentiation and movement strategies in the developing mouse epidermis.

The paper shows that sparse mesenchymal networks behave like a fluid under tension, driven by contact inhibition of locomotion, and identifies this as a new tissue behavior with implications for development and tumorigenesis.

This paper introduces a minimal in vitro assay to study cell intercalation, showing that interfacial tension and migratory forces drive this process in epithelial cells.

The paper shows dynamic forces from tissue movements shape the Kupffers vesicle in zebrafish embryos, confirmed by modeling and laser ablation experiments.

The paper shows how mechanical forces from epithelial and mesenchymal compartments coordinate cell shape and fate to form tissue architecture during hair follicle development.

This paper investigates how 3D viscoelastic drag forces from tailbud tissue drive cell shape changes in the zebrafish embryo's Kupffer's Vesicle during organogenesis.

The paper shows that cell shape and alignment together predict a solid-to-fluid transition in Drosophila germband epithelium during convergent extension.

The paper identifies asymmetric cell volume changes in zebrafish Kupffer's vesicle that drive cell shape changes during epithelial morphogenesis, independent of lumen expansion.