Ioakeim Ampartzidis

Deep generative embeddings of gene expression and splicing reposition the interpretation of single-cell transcriptomic signatures

Crecerelle integrates gene expression and alternative splicing to improve cell-type annotation and uncover regulatory pathways in single-cell transcriptomics.

Extracellular matrix defects destabilise apical cytoarchitecture and mechanical properties during early Down syndrome neurodevelopment

This study shows that ECM defects in Down syndrome neurodevelopment cause apical cytoarchitecture and mechanical property instability in neural stem cell models.

Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation