Karine Dufresne

This study identifies GraXRS as the main activator of TSST-1 at low pH in Staphylococcus aureus, revealing a complex regulatory network in response to vaginal pH changes.

This study shows TSST-1 promotes S. aureus vaginal colonization by activating CD8+ T cells and altering the vaginal microbiota.

The paper identifies PP-HCl as an anti-virulence compound that inhibits TSST-1 production in S. aureus without affecting bacterial growth or vaginal microbiota.