John K. McCormick

This study shows that the RND efflux pump FemT in Staphylococcus aureus helps maintain lipid homeostasis by exporting isoprenoid and carotenoid lipids, preventing oxidative damage.

This paper develops multivalent nanobodies that neutralize multiple S. aureus toxins, showing potent activity in murine models of sepsis and pneumonia.

This study identifies GraXRS as the main activator of TSST-1 at low pH in Staphylococcus aureus, revealing a complex regulatory network in response to vaginal pH changes.

This study identifies the mannose phosphotransferase system (Man-PTS) in Streptococcus pyogenes as important for antimicrobial activity and nasopharyngeal infection, but not skin infection.

This study shows TSST-1 promotes S. aureus vaginal colonization by activating CD8+ T cells and altering the vaginal microbiota.

The paper identifies PP-HCl as an anti-virulence compound that inhibits TSST-1 production in S. aureus without affecting bacterial growth or vaginal microbiota.