Author

Dennis A. DiMaggio

Georgetown UniversityORCID 0000-0002-2093-2345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Shaun R. BrinsmadeiD· 3 shared Carla S. MadutaiD· 1 shared John K. McCormickiD· 1 shared Karine DufresneiD· 1 shared Shahad AlqahtaniiD· 1 shared Won‐Sik Yeo· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 8 mutual co-author links

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3 shared papersMicrobiology

Shaun R. BrinsmadeORCID

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3 papers

Recent·Most cited

MicrobiologyJournal of BacteriologyPeer-reviewedJul 21, 2025

Pyrimidine sufficiency is required for Sae two-component system signaling in Staphylococcus aureus

Dennis A. DiMaggio, Won‐Sik Yeo, Shaun R. Brinsmade

This study shows that pyrimidine biosynthesis is essential for SaeS kinase activity in S. aureus, linking nucleotide metabolism to virulence regulation through membrane integrity.

7 citations

bacteria (other)experimental assay

PhysiologyJournal of BacteriologyPeer-reviewedOct 9, 2024

CodY controls the SaeR/S two-component system by modulating branched-chain fatty acid synthesis in Staphylococcus aureus

Shahad Alqahtani, Dennis A. DiMaggio, Shaun R. Brinsmade

This paper identifies how CodY regulates the SaeRS two-component system in S. aureus by modulating branched-chain fatty acid synthesis through the ilv-leu operon and brnQ2 gene.

12 citations

bacteria (other)proteomics

MicrobiologyJournal of Biological ChemistryPeer-reviewedJun 7, 2024

Discovery of an anti-virulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin 1 (TSST-1) production

Karine Dufresne, Dennis A. DiMaggio, Carla S. Maduta…·John K. McCormick

The paper identifies PP-HCl as an anti-virulence compound that inhibits TSST-1 production in S. aureus without affecting bacterial growth or vaginal microbiota.

17 citationstop 4%

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