Abhishek Chandra

This paper describes a standardized protocol for creating mouse models of bisphosphonate-related and radiation-induced jaw osteonecrosis using minimally invasive surgical and irradiation techniques.

This study shows that early suppression of the pro-inflammatory senescent secretome (SASP) with ruxolitinib reduces chronic bone damage after radiotherapy.

The paper redefines skeletal endothelial heterogeneity by showing the proposed type R population is part of a venous continuum and includes fatty acid-handling endothelial cells.

The paper identifies common differentially regulated microRNAs in skeletal aging and radiation-induced bone deterioration, linking them to WNT pathway modulation and senescence.

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

This study shows that cellular senescence drives bone marrow adiposity in radiation- and aging-associated bone loss through miR-27a upregulation and senolytic treatment reduces BMAT.