The paper identifies common differentially regulated microRNAs in skeletal aging and radiation-induced bone deterioration, linking them to WNT pathway modulation and senescence.

Calcified Tissue International · May 25, 2026Peer-reviewedGenomics

A comprehensive view of somatic mosaicism by single-cell DNA analysis

Lovelace J. Luquette, Tim H. H. Coorens, Abhiram Natu, Milovan Šuvakov, Ann H. Caplin, Mee Sook Jun, Alisa Mo, Joe Pelt, Lisa Anderson, Michele Berselli, Sravya Venkata Bhamidipati, Thomas P. Blanchard, Joseph Brew, Hye-Jung E. Chun, Hyunbin Chun, , Alexej S. Abyzov

The paper uses single-cell DNA sequencing to analyze somatic mosaicism in postmortem lung and colon tissues, revealing mutation heterogeneity, chromosomal abnormalities, and cellular ancestry.

bioRxiv · Oct 31, 2025 · PreprintGenomics

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry

Abhiram Natu, Mrunal K. Dehankar, Reenal Pattni, Milovan Šuvakov, Dmitrii Olisov, Livia Tomasini, Yeongjun Jang, Yi‐Ling Huang, Eva Benito-Garragori, Patrick Hasenfeld, Jan O. Korbel, Alexander Eckehart Urban, Alexej S. Abyzov, Flora Maria Vaccarino

This study uses single-cell whole genome amplification to link somatic mutations to cell identity and ancestry in a live donor.

bioRxiv · Oct 28, 2025 · PreprintGenomics

Exogene: A performant workflow for detecting viral integrations from paired-end next-generation sequencing data

Zachary D. Stephens, Daniel R. O’Brien, Mrunal K. Dehankar, Lewis Rowland Roberts, Ravishankar K. Iyer, Jean‐Pierre Kocher

Exogene detects viral integrations from paired-end sequencing data with high concordance to long-read validation, identifying new integrations in HCC samples.

PLoS ONE · Sep 22, 2021Peer-reviewedBioinformatics

Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimers mouse model

Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace A. Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal K. Dehankar, Cory C. Funk, Jordan Maximillian Wilkins, Анна Степанова, , Eugenia V. Trushina

The paper shows that partial inhibition of mitochondrial complex I protects against neurodegeneration in Alzheimer's mice by improving energy homeostasis, synaptic function, and reducing inflammation.

Communications Biology · Jan 8, 2021Peer-reviewedNeuroscience