Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damage
David Achudhan, Jacob J. Orme, Ritika Sharma, Aqsa Komel, Khubaib Gul Khan, Thomas A White, Nathan K. LeBrasseur, Sundeep Khosla, Sean S. Park, Robert J. Pignolo, Abhishek Chandra
This study shows that early suppression of the pro-inflammatory senescent secretome (SASP) with ruxolitinib reduces chronic bone damage after radiotherapy.
Journal of Bone and Mineral Research · Aug 7, 2026Peer-reviewedCancer Biology