Sundeep Khosla

Cellular senescence is associated with age-related loss of liver zonation and hepatocyte function

This study shows that cellular senescence disrupts liver zonation and hepatocyte function with age by altering gene expression and cell signaling.

Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damage

This study shows that early suppression of the pro-inflammatory senescent secretome (SASP) with ruxolitinib reduces chronic bone damage after radiotherapy.

SenoQuant: One-stop AI software for senescence marker analysis and prediction

SenoQuant is an AI software for analyzing and predicting senescence markers in tissues, offering spatial quantification across imaging modalities and supporting custom models.

Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases

This study identifies sex-specific changes in bone and senescence-related proteins in neurodegenerative diseases using plasma proteomics.

MicroRNA Networks Driving Skeletal Aging and WNT Pathway Modulation

The paper identifies common differentially regulated microRNAs in skeletal aging and radiation-induced bone deterioration, linking them to WNT pathway modulation and senescence.

Comprehensive healthspan assessments and influence of sex as a biological variable in aging rats

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence

This study shows bisphosphonates reduce senescence markers and alter proteomes in multiple cell types, suggesting anti-ageing effects beyond bone health.

Roles of cellular senescence in driving bone marrow adiposity in radiation-and aging-associated bone loss

This study shows that cellular senescence drives bone marrow adiposity in radiation- and aging-associated bone loss through miR-27a upregulation and senolytic treatment reduces BMAT.