Author

Jacob J. Orme

Mayo ClinicORCID 0000-0002-0319-0239Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Abhishek ChandraiD· 1 shared Aqsa Komel· 1 shared David AchudhaniD· 1 shared Khubaib Gul Khan· 1 shared Nathan K. LeBrasseuriD· 1 shared Ritika Sharma· 1 shared Robert J. PignoloiD· 1 shared Sean S. ParkiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Abhishek ChandraORCID

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1 paper

Recent·Most cited

Cancer BiologyJournal of Bone and Mineral ResearchPeer-reviewedAug 7, 2026

Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damage

David Achudhan, Jacob J. Orme, Ritika Sharma…·Abhishek Chandra

This study shows that early suppression of the pro-inflammatory senescent secretome (SASP) with ruxolitinib reduces chronic bone damage after radiotherapy.

DOI 10.1093/jbmr/zjag122

mousehuman